__________ are numbered numerically from top to bottom while __________ are referred by alpha characters from left to right.

In spreadsheet applications, the structure follows a standard format for identifying cells:

Rows run horizontally across the spreadsheet and are identified by numbers (1, 2, 3, 4...) starting from the top and moving downward.

Columns run vertically and are identified by alphabetic characters (A, B, C, D...) starting from the left and moving toward the right.

When we combine these references, any cell in the spreadsheet can be located using the column letter followed by the row number. For example, cell B5 means the intersection of column B and row 5.

The complete statement reads: Rows are numbered numerically from top to bottom while Columns are referred by alpha characters from left to right.