In the following question, four options are given, out of which three are alike in a particular way while one is different. Choose the odd one.

Examining the prime factorization of each number:

$161 = 7 \times 23$

$185 = 5 \times 37$

$253 = 11 \times 23$

$299 = 13 \times 23$

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The numbers 161, 253, and 299 all share a common prime factor of 23.

$161 = 7 \times 23$

$253 = 11 \times 23$

$299 = 13 \times 23$

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The number 185 is the only one that does not have 23 as a prime factor.

$185 = 5 \times 37$

Therefore, 185 is the odd one out.

The correct answer is Option 2.