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Choose the most appropriate option to fill in the blank in the given sentence:

_____you make a wrong choice with regard to your career, you will regret it for the rest of your life.

Solution

✅ Correct Option: 1

The sentence expresses that a single wrong career choice leads to lifelong regret. 'Once' meaning 'as soon as / if ever' fits: 'Once you make a wrong choice..., you will regret it.' 'Since' gives a false causal reading, while 'although' and 'while' wrongly signal contrast.

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